RSK and MSK in MAP kinase signalling.
نویسندگان
چکیده
RSK [for 90 kDa ribosomal S6 kinase (p90rsk); also known as MAPKAP-K1] and MSK (for mitogenand stressactivated protein kinase) constitute a family of protein kinases that mediate signal transduction downstream of MAP kinase cascades. RSK is activated by MAP kinases of the extracellular signalregulated kinase (ERK) family in response to growth factors, many polypeptide hormones, neurotransmitters, chemokines and other stimuli. MSK is also activated by ERK in response to such stimuli, but in addition, it can be activated by p38 family MAP kinases in response to various cellular stress stimuli and proinflammatory cytokines/factors. In mammals, four RSK genes (RSK1-RSK4) and two MSK genes (MSK1 and MSK2) have been identified. RSK and MSK are ubiquitously expressed and many cell types express several members of each family. At present, little is known about specific and overlapping functions of the individual RSK/MSK family members. Orthologues of RSK and MSK have been described in D. melanogaster and C. elegans, but not in yeast or plants.
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ورودعنوان ژورنال:
- Journal of cell science
دوره 119 Pt 15 شماره
صفحات -
تاریخ انتشار 2006